Int J Oral Maxillofac Implants 29 (2014), No. 6 19. Dec. 2014
Int J Oral Maxillofac Implants 29 (2014), No. 6 (19.12.2014)
Page 1429-1434, doi:10.11607/jomi.3758, PubMed:25397806
Body Fat Indices and Biomarkers of Inflammation: A Cross-Sectional Study with Implications for Obesity and Peri-implant Oral Health
Elangovan, Satheesh / Brogden, Kim A. / Dawson, Deborah V. / Blanchette, Derek / Pagan-Rivera, Keyla / Stanford, Clark M. / Johnson, Georgia K. / Recker, Erica / Bowers, Rob / Haynes, William G. / Avila-Ortiz, Gustavo
Purpose: To examine the relationships between three measures of body fat-body mass index (BMI), waist circumference (WC), and total body fat percent-and markers of inflammation around dental implants in stable periodontal maintenance patients.
Materials and Methods: Seventy-three subjects were enrolled in this cross-sectional assessment. The study visit consisted of a physical examination that included anthropologic measurements of body composition (BMI, WC, body fat %); intraoral assessments were performed (full-mouth plaque index, periodontal and peri-implant comprehensive examinations) and peri-implant sulcular fluid (PISF) was collected on the study implants. Levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17, tumor necrosis factor-α, C-reactive protein, osteoprotegerin, leptin, and adiponectin in the PISF were measured using multiplex proteomic immunoassays. Correlation analysis with body fat measures was then performed using appropriate statistical methods.
Results: After adjustments for covariates, regression analyses revealed statistically significant correlation between IL-1β in PISF and WC (R = 0.33; P = .0047).
Conclusion: In this study in stable periodontal maintenance patients, a modest but statistically significant positive correlation was observed between the levels of IL-1β, a major proinflammatory cytokine in PISF, and WC, a reliable measure of central obesity.
Keywords: body composition, cytokines, dental implants, interleukins, obesity, peri-implantitis