The International Journal of Oral & Maxillofacial Implants



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Int J Oral Maxillofac Implants 31 (2016), No. 3     13. May 2016
Int J Oral Maxillofac Implants 31 (2016), No. 3  (13.05.2016)

Page 547-554, doi:10.11607/jomi.4349, PubMed:27183063

Titanium-Zirconium Binary Alloy as Dental Implant Material: Analysis of the Influence of Compositional Change on Mechanical Properties and In Vitro Biologic Response
Lee, Tsunglin James / Ueno, Takeshi / Nomura, Naoyuki / Wakabayashi, Noriyuki / Hanawa, Takao
Purpose: To evaluate the mechanical properties and biologic response of single-phase Ti-Zr alloys cast in higher-purity casting conditions, with comprehensive compositions (from 10 to 90 mol% of Zr).
Materials and Methods: The mechanical properties and in vitro biologic response with proportional increase of Zr to Ti-Zr alloy composition were assessed. Tensile strength, surface hardness, and Young's modulus were examined. The in vitro cell response of the alloys was also tested with mouse osteoblast cells.
Results: Analyses of mechanical tests demonstrated improved strength and reduced Young's modulus on this binary alloy system. In vitro cell culture studies with osteogenic MCT3T-E1 cells exhibited the highest attachment rate with the largest and more mature cells on Ti10Zr, instead of commercially pure Ti, whereas a significantly lower cell attachment rate and delayed alkaline phosphatase-specific activity (ALP) differentiation were detected on Ti50Zr.
Conclusion: The results revealed that the composition did have an impact on the in vitro biologic response. Ti-Zr alloys with 50-50 mol% composition had a decreased biologic response, although the mechanical properties improved. The overall highest strength was Ti with 30 mol% Zr without significant decrease of biologic response.

Keywords: alloy composition, biologic response, dental implant material, mechanical property, titaniumzirconium alloy
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