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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 30 (2015), No. 2     26. Mar. 2015
Int J Oral Maxillofac Implants 30 (2015), No. 2  (26.03.2015)

Page 279-285, doi:10.11607/jomi.3793, PubMed:25830387


Experimental Evaluation of the Effects of Ankaferd Blood Stopper and Collagenated Heterologous Bone Graft on Bone Healing in Sinus Floor Augmentation
Cakir, Merve / Karaca, İnci Rana / Firat, Ayşegül / Kaymaz, Figen / Bozkaya, Suleyman
Purpose: The aim of this study was to evaluate the effect of collagenated heterologous bone graft (CHBG) and Ankaferd Blood Stopper (ABS), a plant extract, on bone healing after sinus floor augmentation.
Materials and Methods: Thirty-six New Zealand rabbits were used. Bilateral sinus augmentation was performed, and 72 bone defects were created. The maxillary sinuses were grafted with four different biomaterials: blood clot (control group), CHBG (Apatos Mix, OsteoBiol, Tecnoss) (graft group), ABS (ABS group), and ABS + CHBG (ABS+graft group). The rabbits were sacrificed at 1, 4, and 8 weeks after surgery. Histochemical and immunohistochemical examinations were performed on all samples. Staining with hematoxylin-eosin and Masson trichrome was performed, and bone marker activity was evaluated.
Results: Lymphocyte infiltration was high at the first week in all groups and decreased from 1 to 8 weeks. All materials were biocompatible. Osteoclast numbers increased in the control group from 1 to 8 weeks and decreased in the other groups. There was no new bone formation in week 1 in all groups. New bone formation increased in all groups from 1 to 8 weeks, and at the fourth week, new bone formation was greater in the ABS and ABS+graft groups than in the other groups. There were osteoclasts around the bone graft materials, but degeneration of the graft was seen only in the ABS+graft group at week 8.
Conclusion: ABS accelerates bone healing in sinus augmentation procedures and can be used alone or with CHBG. CHBG has osteoconductive properties, and ABS can accelerate bone graft degeneration.

Keywords: Ankaferd Blood Stopper, bone healing, collagenated heterologous bone graft, sinus augmentation, tartrate-resistant acid phosphatase