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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 30 (2015), No. 3     19. May 2015
Int J Oral Maxillofac Implants 30 (2015), No. 3  (19.05.2015)

Page 707-714, doi:10.11607/jomi.3956, PubMed:26009923


Effect of Targeted Delivery of Bone Morphogenetic Protein-2 on Bone Formation in Type 1 Diabetes
Santana, Ronaldo Barcellos de / Trackman, Phillip C.
Purpose: Bone formation and healing are diminished in experimental type 1 diabetes. The present study investigated whether controlled local release of recombinant human bone morphogenetic protein 2 (rhBMP-2) stimulates bone defect healing in diabetes as a consequence of its anabolic effects on bone.
Materials and Methods: Bilateral experimental circular bone defects were created in the temporal bones of 64 BALB/ cByJ mice. Defects were treated with acellular collagen sponge plus 0.4 or 1.8 μg of rhBMP-2 per defect, and untreated defects served as controls. The healing of the defects over a 14-day period in diabetic and nondiabetic mice was analyzed histomorphometrically.
Results: Diabetes inhibited bone formation in both untreated and BMP-treated bone defects. Controlled local release of rhBMP-2 significantly stimulated bone formation in diabetic animals, bringing it nearly to normal levels, and enhanced bone regeneration in normal animals.
Conclusion: Recombinant human BMP-2 may be beneficial in treating deficient intramembranous bone formation in diabetes.

Keywords: bone regeneration, diabetes, recombinant human bone morphogenetic protein-2