We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
The International Journal of Oral & Maxillofacial Implants



Forgotten password?


Int J Oral Maxillofac Implants 30 (2015), No. 3     19. May 2015
Int J Oral Maxillofac Implants 30 (2015), No. 3  (19.05.2015)

Page 707-714, doi:10.11607/jomi.3956, PubMed:26009923

Effect of Targeted Delivery of Bone Morphogenetic Protein-2 on Bone Formation in Type 1 Diabetes
Santana, Ronaldo Barcellos de / Trackman, Phillip C.
Purpose: Bone formation and healing are diminished in experimental type 1 diabetes. The present study investigated whether controlled local release of recombinant human bone morphogenetic protein 2 (rhBMP-2) stimulates bone defect healing in diabetes as a consequence of its anabolic effects on bone.
Materials and Methods: Bilateral experimental circular bone defects were created in the temporal bones of 64 BALB/ cByJ mice. Defects were treated with acellular collagen sponge plus 0.4 or 1.8 μg of rhBMP-2 per defect, and untreated defects served as controls. The healing of the defects over a 14-day period in diabetic and nondiabetic mice was analyzed histomorphometrically.
Results: Diabetes inhibited bone formation in both untreated and BMP-treated bone defects. Controlled local release of rhBMP-2 significantly stimulated bone formation in diabetic animals, bringing it nearly to normal levels, and enhanced bone regeneration in normal animals.
Conclusion: Recombinant human BMP-2 may be beneficial in treating deficient intramembranous bone formation in diabetes.

Keywords: bone regeneration, diabetes, recombinant human bone morphogenetic protein-2