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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 32 (2017), No. 2     17. Mar. 2017
Int J Oral Maxillofac Implants 32 (2017), No. 2  (17.03.2017)

Page 282-290, doi:10.11607/jomi.5074, PubMed:28291848


Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model
Cardoso, Marcio Vivan / Chaudhari, Amol / Yoshihara, Kumiko / Mesquita, Marcelo Ferraz / Yoshida, Yasuhiro / Van Meerbeek, Bart / Vandamme, Katleen / Duyck, Joke
Purpose: To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration.
Materials and Methods: Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un)coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with α = .05 was used to statistically compare BF and BIC of the coated and uncoated implants.
Results: Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P < .05) and for both healing periods (P < .05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P < .05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P < .05).
Conclusion: These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.

Keywords: bone, organic coating, osseointegration, pullulan, titanium implant