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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 33 (2018), No. 5     4. Oct. 2018
Int J Oral Maxillofac Implants 33 (2018), No. 5  (04.10.2018)

Page 1047-1056, doi:10.11607/jomi.6292, PubMed:30231091


Recombinant Human Platelet-Derived Growth Factor-BB in Human Alveolar Ridge Augmentation: A Review of the Literature
Scheines, Cynthia / Hokett, Steven D. / Katancik, James A.
Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use.
Materials and Methods: Three electronic searches of the MEDLINE database were performed.
Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures.
Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

Keywords: alveolar ridge augmentation, bone regeneration, recombinant platelet-derived growth factor BB, rhPDGF-BB