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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 34 (2019), No. 5     29. Oct. 2019
Int J Oral Maxillofac Implants 34 (2019), No. 5  (29.10.2019)

Page 1237-1245, doi:10.11607/jomi.7343, PubMed:31528867


Adjunctive Systemic Metronidazole to Nonsurgical Therapy of Peri-implantitis with Intrabony Defects: A Retrospective Case Series Study
Liñares, Antonio / Pico, Alexandre / Blanco, Carlota / Blanco, Juan
Purpose: To show the clinical and radiographic results of intrabony peri-implantitis lesions treated nonsurgically with adjunctive systemic metronidazole with a mean follow-up of 50 months.
Materials and Methods: Subjects diagnosed with peri-implantitis (probing depth ≥ 5 mm with concomitant bleeding on probing and/or suppuration) with radiographic evidence of intrabony defects > 2 mm were included in this study. Implants affected received one session of nonsurgical mechanical debridement with ultrasonic and steel curettes. Systemic metronidazole was immediately prescribed for 7 days. Clinical and radiographic variables were registered at baseline and at the end of follow-up.
Results: Eighteen patients and 25 implants were included in this investigation. At baseline, the mean radiographic bone level and intrabony component were 4.52 ± 2.14 mm and 3.93 ± 1.51 mm, respectively. After a mean follow-up of 54 (range: 12 to 108) months, the mean radiographic bone level reduction was 2.6 ± 0.21 mm, and the intrabony component reduction was 2.85 ± 0.37 mm (P < .05). A mean probing depth reduction of 4.66 ± 1.33 mm was observed (P < .05).
Conclusion: Within the limits of this study, nonsurgical treatment of peri-implantitis with the adjunctive administration of systemic metronidazole has shown potential effectiveness in terms of probing depth and radiographic defect reduction after a mean follow-up of 54 months.

Keywords: metronidazole, nonsurgical peri-implant therapy, peri-implantitis, radiographic bone loss