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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 35 (2020), No. 4     30. July 2020
Int J Oral Maxillofac Implants 35 (2020), No. 4  (30.07.2020)

Page 739-748, doi:10.11607/jomi.8067, PubMed:32724925


Histologic and Micro-CT Analyses at Implants Placed Immediately After Maxillary Sinus Elevation Using Large or Small Xenograft Granules: An Experimental Study in Rabbits
Masuda, Katsuhiko / Silva, Erick Ricardo / Alccayhuaman, Karol Alí Apaza / Botticelli, Daniele / Xavier, Samuel Porfirio
Purpose: To compare the osseointegration at the portion of the implant within the elevated space after sinus elevation using different sizes of xenograft.
Materials and Methods: Eighteen New Zealand rabbits were selected, antrostomies were prepared bilaterally through the nasal dorsum, and the sinus mucosa was elevated. Deproteinized bovine bone mineral with granules of either 1 to 2 mm (large sites) or 0.250 to 1.0 mm (small sites) were randomly used to fill the elevated space of the two sinuses. Subsequently, mini-implants were placed through the antrostomy, one in each sinus. The animals were euthanized 2, 4, and 8 weeks after surgery, six animals for each group. Microcomputed tomography (micro-CT) and histologic analyses were performed.
Results: In the elevated space, at the histologic analysis after 2 weeks of healing, new bone formed on the implant surface was found in fractions of 18.8% ± 6.8% and 15.8% ± 9.6% in the large and small sites, respectively (P = .249). After 4 weeks, the respective fractions of new bone were 20.3% ± 3.5% and 23.3% ± 5.6% (P = .249). After 8 weeks, the proportions reached 33.9% ± 9.5% and 28.5% ± 10.3% (P = .173), respectively. At the micro-CT analysis, bone-to-implant contact percentage (BIC%) was 21.0% ± 2.3% and 21.2% ± 2.4% in the large and small sites, respectively (P = 1.000). The respective proportions of BIC% at the large and small sites were 20.5% ± 3.3% and 23.4% ± 5.4% after 4 weeks (P = .463), and 23.0% ± 2.7% and 25.8% ± 4.1% after 8 weeks (P = .249).
Conclusion: The use of xenograft granules of different dimensions resulted in similar amounts of bone-to-implant contact at implants placed simultaneously with sinus floor augmentation.

Keywords: biomaterials, bone graft, histology