We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
The International Journal of Oral & Maxillofacial Implants



Forgotten password?


Int J Oral Maxillofac Implants 23 (2008), No. 4     15. July 2008
Int J Oral Maxillofac Implants 23 (2008), No. 4  (15.07.2008)

Page 641-647, PubMed:18807559

The Effect of Chemical and Nanotopographical Modifications on the Early Stages of Osseointegration
Meirelles, Luiz / Currie, Fredrik / Jacobsson, Magnus / Albrektsson, Tomas / Wennerberg, Ann
Purpose: To investigate the effect of chemically modified implants with similar microtopographies but different nanotopographies on early stages of osseointegration.
Materials and Methods: Forty screw-shaped implants were placed in 10 New Zealand white rabbits. The implant surface modifications investigated in the present study were (1) blasting with TiO2 and further (2) fluoride treatment or (3) modification with nano-hydroxyapatite. Surface evaluation included topographical analyses with interferometry, morphologic analyses with scanning electron microscopy, and chemical analyses with x-ray photoelectron spectroscopy. Bone response was investigated with the removal torque test, and histologic analyses were carried out after a healing period of 4 weeks.
Results: Surface roughness parameters showed a slight decrease of the average height deviation for the fluoride-treated compared to the blasted (control) and nano-hydroxyapatite implants. Scanning electron microscopic images at high magnification indicated the presence of nanostructures on the chemically modified implants. Chemical analyses revealed the presence of titanium, oxygen, carbon, and nitrogen in all implant groups. The blasted-fluoride group revealed fluoride, and the blasted-nano HA group calcium and phosphorus with simultaneous decrease of titanium and oxygen. Removal torque values revealed an increased retention for the chemically modified implants that exhibit specific nanotopography. The histologic analyses demonstrated immature bone formation in contact with the implant surface in all groups, according to the healing period of the experiment.
Conclusion: Chemical modifications used in the present study were capable of producing a particular nanotopography, and together with the ions present at the implant surface, may explain the increased removal torque values after a healing period of 4 weeks.

Keywords: dental implants, hydroxyapatite, nanotopography, osseointegration, surface modification, titanium fluoride