We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
The International Journal of Oral & Maxillofacial Implants
Login:
username:

password:

Plattform:

Forgotten password?

Registration

Int J Oral Maxillofac Implants 20 (2005), No. 5     15. Sep. 2005
Int J Oral Maxillofac Implants 20 (2005), No. 5  (15.09.2005)

Page 703-712


Bone Regeneration in Standardized Bone Defects with Autografts or Bone Substitutes in Combination with Platelet Concentrate: A Histologic and Histomorphometric Study in the Mandibles of Minipigs
Jensen, Simon Storgard / Broggini, Nina / Weibrich, Gernot / Hjørting-Hansen, Erik / Schenk, Robert / Buser, Daniel
Purpose: To evaluate the effect of the addition of platelet concentrate (PC) to autografts or bone substitutes on bone regeneration in standardized bone defects.
Materials and Methods: Three standardized bone defects were prepared in both mandibular angles of 12 adult minipigs. The defects were grafted with autograft, anorganic bovine bone, or synthetic b-tricalcium phosphate (b-TCP). PC was added to only 1 side. The animals were divided into 4 groups, which were sacrificed at 4 different time points (1, 2, 4, and 8 weeks) for histologic and histomorphometric analysis. The concentrations of platelets and growth factors were measured to identify correlation to the histologic and histomorphometric results.
Results: No correlation was found between platelet count in whole blood and platelet count in PC (rp = 0.36). Furthermore, no correlation could be demonstrated between the platelet count of the PC and the concentrations of PDGF-AB (rp = -0.27) and TGF-b (rp = 0.34). There were no signs of a stimulating effect of PC on bone formation in combination with autografts or bone substitutes at any time point (P = .89). Addition of PC did not alter the pattern of graft degradation.
Discussion: The present study underlines the need for further investigation to identify the optimal concentrations of platelets and combinations of growth factors to achieve a predictable stimulatory effect on bone regeneration. One of the first steps to achieve this goal will be the development of a reliable method for the procurement of PC.
Conclusion: PC had no impact on bone formation and graft degradation in standardized bone defects in the mandibles of minipigs.

Keywords: autogenous bone grafting, bone regeneration, bone substitutes, growth factors, platelet concentrates, platelet-rich plasma