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The International Journal of Oral & Maxillofacial Implants



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Int J Oral Maxillofac Implants 20 (2005), No. 5     15. Sep. 2005
Int J Oral Maxillofac Implants 20 (2005), No. 5  (15.09.2005)

Page 703-712

Bone Regeneration in Standardized Bone Defects with Autografts or Bone Substitutes in Combination with Platelet Concentrate: A Histologic and Histomorphometric Study in the Mandibles of Minipigs
Jensen, Simon Storgard / Broggini, Nina / Weibrich, Gernot / Hjørting-Hansen, Erik / Schenk, Robert / Buser, Daniel
Purpose: To evaluate the effect of the addition of platelet concentrate (PC) to autografts or bone substitutes on bone regeneration in standardized bone defects.
Materials and Methods: Three standardized bone defects were prepared in both mandibular angles of 12 adult minipigs. The defects were grafted with autograft, anorganic bovine bone, or synthetic b-tricalcium phosphate (b-TCP). PC was added to only 1 side. The animals were divided into 4 groups, which were sacrificed at 4 different time points (1, 2, 4, and 8 weeks) for histologic and histomorphometric analysis. The concentrations of platelets and growth factors were measured to identify correlation to the histologic and histomorphometric results.
Results: No correlation was found between platelet count in whole blood and platelet count in PC (rp = 0.36). Furthermore, no correlation could be demonstrated between the platelet count of the PC and the concentrations of PDGF-AB (rp = -0.27) and TGF-b (rp = 0.34). There were no signs of a stimulating effect of PC on bone formation in combination with autografts or bone substitutes at any time point (P = .89). Addition of PC did not alter the pattern of graft degradation.
Discussion: The present study underlines the need for further investigation to identify the optimal concentrations of platelets and combinations of growth factors to achieve a predictable stimulatory effect on bone regeneration. One of the first steps to achieve this goal will be the development of a reliable method for the procurement of PC.
Conclusion: PC had no impact on bone formation and graft degradation in standardized bone defects in the mandibles of minipigs.

Keywords: autogenous bone grafting, bone regeneration, bone substitutes, growth factors, platelet concentrates, platelet-rich plasma