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The International Journal of Oral & Maxillofacial Implants



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Int J Oral Maxillofac Implants 18 (2003), No. 6     15. Nov. 2003
Int J Oral Maxillofac Implants 18 (2003), No. 6  (15.11.2003)

Page 807-811

Effects of Local Administration of Growth Hormone in Peri-implant Bone: An Experimental Study with Implants in Rabbit Tibiae
Tresguerres, Isabel F. / Blanco, Luis / Clemente, Celia / Tresguerres, Jesús A. F.
Purpose: The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH).
Materials and Methods: Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy.
Results: The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P < .05).
Discussion: Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum.
Conclusions: Local administration of GH at the time of implant placement could enhance peri-implant bone reaction.