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The International Journal of Oral & Maxillofacial Implants



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Int J Oral Maxillofac Implants 16 (2001), No. 4     15. Aug. 2001
Int J Oral Maxillofac Implants 16 (2001), No. 4  (15.08.2001)

Page 563-571

Histologic Evaluation of the Osteoinductive Property of Autogenous Demineralized Dentin Matrix on Surgical Bone Defects in Rabbit Skulls Using Human Amniotic Membrane for Guided Bone Regeneration
Gomes, Mônica Fernandes / Anjos, Mário James da Silva dos / Nogueira, Terezinha de Oliveira / Guimarães, Sérgio Augusto Catanzaro
The aim of this investigation was to evaluate the osteoinductive property of autogenous demineralized dentin matrix (ADDM) on experimental surgical bone defects in the parietal bone of rabbits using the guided bone regeneration (GBR) technique incorporating human amniotic membrane (HAM). Thirty-six rabbits were divided into 2 groups, HAM and ADDM+HAM. It was possible to conclude that HAM did not interfere with bone repair and was resorbed. Slices of ADDM induced direct bone formation and were incorporated by the newly formed bone tissue and remodeled. The bone defects healed faster in the ADDM+HAM group than in the group with HAM only.

Keywords: autogenous demineralized dentin matrix, biologic dressings, bone repair, guided tissue regeneration, human amniotic membrane