We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
The International Journal of Oral & Maxillofacial Implants



Forgotten password?


Int J Oral Maxillofac Implants 15 (2000), No. 2     15. Apr. 2000
Int J Oral Maxillofac Implants 15 (2000), No. 2  (15.04.2000)

Page 175-184

Myelointegration of Titanium Implants: B Lymphopoiesis and Hemopoietic Cell Proliferation in Mouse Bone Marrow Exposed to Titanium Implants
Rahal, M. Dwayne / Delorme, Danielle / Brånemark, Per-Ingvar / Osmond, Dennis G.
Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found that an implant-marrow interface with associated giant cells persists for at least 1.5 years. Precursor B cells show early increases in number and proliferative activity. At later intervals, however, they do not differ significantly from controls, and there are no perturbations in spatial localization of either B lineage cells or DNA-synthesizing hemopoietic cells. The results of this investigation in mice demonstrate that, following initial marrow regeneration and fluctuating precursor B cell activity, and despite the presence of giant cells, titanium implants apparently become well-tolerated by directly apposed bone marrow cells in a lasting state of myelointegration.

Keywords: B lymphopoiesis, bone marrow, giant cells, hemopoietic microenvironment, titanium implants