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The International Journal of Oral & Maxillofacial Implants



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Int J Oral Maxillofac Implants 13 (1998), No. 5     15. Oct. 1998
Int J Oral Maxillofac Implants 13 (1998), No. 5  (15.10.1998)

Page 620-629

Wound Healing Around Endosseous Implants in Experimental Diabetes
Nevins, Marc L. / Karimbux, Nadeem Y.
Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.

Keywords: dental implants, diabetes, osseointegration, wound healing