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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 27 (2012), No. 1     15. Feb. 2012
Int J Oral Maxillofac Implants 27 (2012), No. 1  (15.02.2012)

Page 95-101, PubMed:22299085


Injectable Magnesium-Enriched Hydroxyapatite Putty in Peri-Implant Defects: A Histomorphometric Analysis in Pigs
Crespi, Roberto / Capparè, Paolo / Addis, Alessandro / Gherlone, Enrico
Purpose: The purpose of this study was to evaluate the healing of an injectable mixture of nanoparticles of magnesium-enriched hydroxyapatite (mHA) in peri-implant defects.
Materials and Methods: Thirty-two dental implants were placed in 16 tibiae of eight female Large White pigs. In each animal, four implant beds (two sites each tibia) with medial three-wall intrabony defects were prepared. Via random selection, one bone defect in each tibia was filled with injectable mHA putty (n = 16, test group), whereas the other defect was not filled (n = 16, control group). Two animals were sacrificed after 2 weeks, two after 4 weeks, two after 6 weeks, and two after 8 weeks. In all, 32 block section samples were obtained for histologic and histomorphometric analyses.
Results: The test group exhibited statistically significantly higher values for bone-to-implant contact (BIC) and lower amounts of connective tissue (CT) over time. The test group showed a remarkable increase in vital bone values between 6 and 8 weeks after implant placement. After 8 weeks, the injectable mHA was almost completely resorbed.
Conclusions: Injectable mHA putty could be a useful and suitable bone grafting material in peri-implant defects.

Keywords: animal study, bone graft, hydroxyapatite, magnesium-enriched hydroxyapatite, peri-implant defect