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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 12 (1997), No. 3     1. May 1997
Int J Oral Maxillofac Implants 12 (1997), No. 3  (01.05.1997)

Page 403-411


A New Animal Model for Maxillary Sinus Floor Augmentation: Evaluation Parameters
Kirker-Head / Nevins / Palmer / Nevins / Schelling
This study describes a novel animal model of the maxillary sinus floor augmentation procedure used to assess bone formation during 12 weeks in response to a recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponse (ACS) sinus implant. A buffer-ACS implant was used as a control. Animal response was monitored using computerized tomography and physical, hematologic, gross pathologic, and histologic evaluations. The rhBMP-2/ACS implants maintained a relatively constant size postsurgery and showed a time-dependent increase in mineralization. The buffer/ACS control implants failed to mineralize and were resorbed by 4 weeks. The model served effectively and without complication. Results indicate rhBMP-2/ACS implants deserve consideration as alternatives to traditional grafting procedures.