We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
The International Journal of Oral & Maxillofacial Implants



Forgotten password?


Int J Oral Maxillofac Implants 28 (2013), No. 1     1. Feb. 2013
Int J Oral Maxillofac Implants 28 (2013), No. 1  (01.02.2013)

Page 51-56, doi:10.11607/jomi.2667, PubMed:23377047

Maxillary Sinus Grafting with Biphasic Calcium Phosphate Ceramics: Clinical and Histologic Evaluation in Man
Mangano, Carlo / Perrotti, Vittoria / Shibli, Jamil A. / Mangano, Francesco / Ricci, Laura / Piattelli, Adriano / Iezzi, Giovanna
Purpose: To evaluate the clinical and histologic aspects of bone formation in maxillary sinus augmentation using macroporous biphasic calcium phosphate (MBCP) comprising hydroxyapatite/tricalcium phosphate (HA/TCP) 60/40 as bone-grafting material.
Materials and Methods: A total of 10 patients and 12 sinuses grafted with MBCP in two-stage sinus augmentation were included in the present study. After a healing period of 6 months, bone core biopsies were harvested during implant insertion and evaluated under light microscopy.
Results: The histologic examination showed that the MBCP particles were in close contact with new bone in all biopsies. Histomorphometric evaluation demonstrated that newly formed bone constituted 28.3% ± 2.7%, residual grafted material 27.3% ± 1.2%, and marrow spaces 45.9% ± 1.9%.
Conclusions: Histologic investigation showed that the MBCP grafted particles were embedded and integrated in the newly formed bone; this bone was in close and tight contact with the biomaterial particles. Data from the preliminary results demonstrated that MBCP is a biocompatible and osteoconductive material that can be successfully used as a grafting material for sinus floor augmentation.

Keywords: bone regeneration, biphasic calcium phosphate, human histology, sinus augmentation