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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 28 (2013), No. 2     15. Mar. 2013
Int J Oral Maxillofac Implants 28 (2013), No. 2  (15.03.2013)

Page 432-443, doi:10.11607/jomi.2782, PubMed:23527345


Use of a Perforated Scaffold-Retaining Abutment to Achieve Vertical Bone Regeneration Around Dental Implants in the Minipig
Catros, Sylvain / Wen, Bo / Schleier, Peter / Shafer, David / Dard, Michel / Obrecht, Marcel / Freilich, Martin / Kuhn, Liisa
Objective: To evaluate the effect of perforated scaffold retainers used in conjunction with dental implants and osteoinductive scaffolds to regenerate vertical supracrestal alveolar bone in an intraoral minipig model.
Materials and Methods: Three months after extraction of mandibular premolars and first molars from six adult minipigs, two titanium (Ti) custom implants were placed bilaterally in the edentulous mandibles for a total of four implants per animal. The upper 2.5 mm of the implant was left above bone level and covered with: (1) wide-neck healing caps; (2) perforated, overhanging custom scaffold retainers (umbrellas); or (3) scaffold retainers and demineralized minipig bone allograft (DBM) and nonglycosylated bone morphogenetic protein 2 (ng/rhBMP-2)-treated implants. All constructs were submerged beneath soft tissue flaps for 8 weeks. Two dental implant surfaces were compared: SLA and SLActive. Samples were retrieved after 8 weeks and analyzed by radiography, micro-computed tomography and histomorphometry.
Results: All implants were stable at the end of the experiment. Histomorphometry revealed that the use of the scaffoldretaining umbrellas led to increased, but not statistically significant, vertical bone regeneration as compared to the use of wide-neck healing caps (1.0 ± 0.4 mm vs 0.6 ± 0.3 mm). The combination of DBM and ng/rhBMP-2 released from the surface of the SLA implant resulted in the greatest amount of vertical bone regeneration (2.1 ± 0.2 mm). The bone-to-implant contact was similar for all groups. Mucosal dehiscence areas with healing cap or custom scaffold retainer exposures were reduced in the presence of ng/rhBMP-2.
Conclusions: The combined use of custom perforated Ti scaffold retainers, DBM, and ng/rhBMP-2 regenerated a substantial amount of vertical supracrestal alveolar bone around Ti implants in an intraoral minipig model.