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The International Journal of Oral & Maxillofacial Implants
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Int J Oral Maxillofac Implants 30 (2015), No. 6     23. Nov. 2015
Int J Oral Maxillofac Implants 30 (2015), No. 6  (23.11.2015)

Page 1431-1436, doi:10.11607/jomi.3943, PubMed:26478977


Levels of Osteoclastogenesis-Related Factors in the Peri-Implant Crevicular Fluid and Clinical Parameters of Immediately Loaded Implants in Patients with Osteopenia: A Short-Term Report
Onuma, Tatiana / Aquiar, Kelly / Duarte, Poliana Mendes / Feres, Magda / Giro, Gabriela / Coelho, Paulo / Cassoni, Alessana / Shibli, Jamil Awad
Purpose: The aim of this prospective controlled study was to evaluate the influence of osteopenia on the levels of osteoclastogenesis-related factors in the peri-implant crevicular fluid (PICF) and on the clinical parameters of immediately loaded implants.
Materials and Methods: This study included 24 patients who received at least two implants in the mandible, with restorations delivered 48 hours after implant placement. Patients were divided into control (n = 11) and osteopenia (n = 13) groups. Seven days after implant placement (baseline) and 4 months after implant placement, PICF samples were obtained, and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, suppuration, probing depths, clinical attachment levels) were measured. A commercially available enzyme-linked immunosorbent assay was used to analyze PICF samples for levels of soluble receptor activator of nuclear factor of κB ligand (sRANKL) and osteoprotegerin (OPG). At the 4-month follow-up visit, the implant-supported restorations were removed and periapical radiographs were acquired to evaluate bone loss around the implants.
Results: Eighty-eight immediately loaded implants were included in this study (38 in the control group, 50 in the osteopenia group). The RANKL and OPG levels, the RANKL/OPG ratio, and the clinical parameters were similar between the groups at both time points. However, the levels of these factors in PICF differed significantly between baseline and 4 months after surgery.
Conclusion: Within the limitations of this short-term study, it can be concluded that osteopenia does not influence the PICF levels of osteoclastogenesis-related factors in immediately loaded implants after 4 months of loading.

Keywords: dental implants, dental implant loading, immediate loading, osteopenia, osteoporosis, osteoprotegerin, RANK ligand, receptor activator of nuclear factor-kappa B